The Eighth Histocompatibility Workshop
The Eighth Histocompatibility workshop, organized by Paul Terasaki and held in Los Angeles in February of 1980, was comprised of 130 participating laboratories testing 720 sera against 37,763 different cells. These studies allowed the HLA-DR locus to be more clearly defined and provided additional clarification of the newly-defined “MB” and “MT” specificities, which in subsequent workshops were shown to be encoded by genes of the HLA-DQ locus. There was also a cellular component, in which 31 laboratories used 115 selected homozygous typing cells to test cells from 2,565 individuals and 411 families. Because a large number of families were studied throughout the workshop, the data reference tables prepared from the results, giving gene, antigen and haplotype frequencies in 34 different ethnic groups, remained the standard benchmark throughout the next decade. Components of the workshop also dealt with the relationship between histocompatibility testing and transplantation outcome and studied the relationship between HLA and susceptibility to diseases such as diabetes, rheumatoid arthritis and multiple sclerosis. A total of 14 new specificities were given WHO designations following the eighth workshop.
Reference: Terasaki PI, ed. Histocompatibility Testing 1980. Los Angeles: UCLA Tissue Typing Laboratory, 1980.