Pharmacogenetics and HLA

Coordinators: Clara Gorodezky and Maria Bettinotti

Serious adverse reactions to some drugs are associated with certain HLA alleles in some ethnic groups, but have not been investigated in other populations. The project will include a retrospective study of HLA alleles in patients of different ethnic groups who had adverse reactions to carbamazepine. Additional associations may be established for other drugs with increasing awareness of possible immunogenetic predisposition.