High-resolution KIR in populations
Project leaders: Jill Hollenbach, Paul Norman and Danillo Augusto
Detailed project description:
The goal of this ongoing project is to characterize the nature and extent of KIR allelic diversity across human populations using Next Generation Sequencing (NGS). Participating labs will perform high-resolution KIR genotyping in unrelated individuals from diverse populations. Studies in families will also be conducted in order to define phased KIR haplotypes through segregation analysis.
Milestones in years:
2019: Participating lab registration
2020-2021: Completion of QC
2022: Final data collection
Data required (number, type of data, inclusion/exclusion criteria):
- High resolution allelic KIR genotyping
Samples required (if applicable, number, type of samples, inclusion/exclusion criteria):
- Samples from individuals representing diverse worldwide population
- Families, in order to characterize KIR haplotypes at high resolution
Reagents/additional assays required:
- All participants performing genotyping locally will be asked to validate methods using a small control panel
Data infrastructure required:
TBD