Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0.

Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0.

Hurley CK, Kempenich J, Wadsworth K, Sauter J, Hofmann JA, Schefzyk D, Schmidt AH, Galarza P, Cardozo MBR, Dudkiewicz M, Houdova L, Jindra P, Sorensen BS, Jagannathan L, Mathur A, Linjama T, Torosian T, Freudenberger R, Manolis A, Mavrommatis J, Cereb N, Manor S, Shriki N, Sacchi N, Ameen R, Fisher R, Dunckley H, Andersen I, Alaskar A, Alzahrani M, Hajeer A, Jawdat D, Nicoloso G, Kupatawintu P, Cho L, Kaur A, Bengtsson M, Dehn J.

HLA. 2020 Jan 22. doi: 10.1111/tan.13811. [Epub ahead of print, open access]

Version 3.0.0 catalog of common, intermediate and well-documented (CIWD) HLA-A, -B,-C, -DRB1, -DRB3, -DRB4, -DRB5, -DQB1 and -DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two-field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well-documented (≥5 occurrences) or not-CIWD. The aim of this study, a component of the 18th International HLA and Immunogenetics Workshop, was to collate the most comprehensive and diverse analysis of HLA and estimate frequencies in different geographic/ancestral/ ethnic population groups.

Version 1.0.0 of the CWD catalogue was published by Cano et al. (2007). Version 2.0.0 of the CWD catalogue was published by Mack et al. (2013) and pertains to the HLA-A, HLA-B, HLA-C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1 alleles, as well as to the G and P groups at these loci. Other catalogues of CWD include that published by Sanchez-Mazas et al. (2017) focused on European populations and He et al. (2018) focused on the Chinese unrelated hematopoietic stem cell registry.

Differences of CIWD version 3.0.0 from earlier versions include:

  • Based on IMGT/HLA version 3.31.0 database (January 2018)
  • More global in scope
  • Based on 14-15 million alleles at each locus, identified by DNA sequencing
  • Because consecutive individuals, provides denominator allowing frequency to be calculated
  • Common category is broader, captures more alleles; additional category added (intermediate) (C>I>WD)
  • Primary data are available for further analysis

The CIWD catalogue is available as PDF-formatted tables in the on-line publication in the journal HLA. This website provides MS Excel versions of the same tables as well as an expanded G level table.

Additional projects related to this CIWD will be coordinated through the 18th International HLA and Immunogenetics Workshop.

Download CIWD 3.0.0 data:

  1. Comparison of HLA P group two-field assignments among CIWD catalogs: HLA-A, -B, -C, -DRB1, -DRB3/4/5, -DQB1, -DPB1
  2. Comparison of HLA G group two-field assignments among CIWD catalogs: HLA-A, -B, -C, -DRB1, -DQB1, -DPB1 [Note: Table expanded from that shown in publication.]
  3. CIWD status of observed non-expressed HLA–A, -B, -C, -DRB1, -DRB3/4/5, -DQB1, -DPB1 assignments
  4. HLA-A allele summary [Note: Primary data including all alleles observed in the study.]
  5. HLA-B allele summary [Note: Primary data including all alleles observed in the study.]
  6. HLA-C allele summary [Note: Primary data including all alleles observed in the study.]
  7. HLA-DRB1 allele summary [Note: Primary data including all alleles observed in the study.]
  8. HLA-DRB3 allele summary [Note: Primary data including all alleles observed in the study.]
  9. HLA-DRB4 allele summary [Note: Primary data including all alleles observed in the study.]
  10. HLA-DRB5 allele summary [Note: Primary data including all alleles observed in the study.]
  11. HLA-DQB1 allele summary [Note: Primary data including all alleles observed in the study.]
  12. HLA-DPB1 allele summary [Note: Primary data including all alleles observed in the study.]
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