Category Archives: Immunogenetics

Project: High-resolution KIR in populations

High-resolution KIR in populations Project leaders: Jill Hollenbach, Paul Norman and Danillo Augusto Detailed project description: The goal of this ongoing project is to characterize the nature and extent of KIR allelic diversity across human populations using Next Generation Sequencing (NGS). Participating labs will perform high-resolution KIR genotyping in unrelated individuals from diverse populations. Studies…

Project: Immunogenetics of Aging

Immunogenetics of Aging Project Leaders: Elissaveta Naumova, Milena Ivanova and Graham Pawelec Detailed project description: Deterioration of the immune system with aging is associated with an increased  susceptibility to infectious diseases, cancer and autoimmune disorders. Many studies have focused on age-associated changes in immune functions which might contribute to these pathologies. It has been demonstrated…

Project: Full-length HLA allele-specific hemizygous Sanger sequencing

Extension of incomplete HLA allele sequences in the IPD-IMGT/HLA database Project leaders: Marcel GJ Tilanus, Christien EM Voorter, Mathijs Groeneweg Detailed project description: The goal of this component is to extend sequences of as many incompletely covered HLA alleles as possible by full length unambiguous Sanger Sequencing. All laboratories can participate by including unique samples…

Project: TCR-HLA Interaction

T cell receptor-HLA Interaction Project leaders: Sami Djoulah & Emmanuel Mignot The T cell receptor is the natural receptor of the HLA-peptide complex and interacts directly with MHC molecules, notably their CDR regions. The goal of this project will be to combine analysis of TCR and HLA in the context of disease, vaccination/immune alterations and…

Project: HLA Allele Catalogue

The HLA Allele Cataloguing Project Project leaders: Faviel Gonzalez, Derek Middleton, Kazutoyo Osoegawa & Medhat Askar Detailed project description: In this project participants are invited to submit data of samples of HLA alleles that are novel, classified as rare or with no enough information in the Allele Frequency Net Database (AFND, http://www.allelefrequencies.net). The project has…

Project: Pharmacogenetics and HLA

Pharmacogenetics and HLA Coordinators: Clara Gorodezky and Maria Bettinotti Serious adverse reactions to some drugs are associated with certain HLA alleles in some ethnic groups, but have not been investigated in other populations. The project will include a retrospective study of HLA alleles in patients of different ethnic groups who had adverse reactions to carbamazepine. Additional…

Project: HLA-DP haplotypes

DPA1-promotor-DPB1 haplotypes Project leaders: Dianne De Santis, Effie Petersdorf, Marcel Tilanus HLA-DPA1 and HLA-DPB1 orientation is unique in the way that they share a promoter region. In contrast to other HLA class II genes, HLA-DPA1 and HLA-DPB1 genes are oriented head to head overlapping 2.4 kb in the promoter region. It has been described that…

Project: HLA Haplotypes in Families

HLA Haplotypes in Families by NGS Project leaders: Medhat Askar & Kazutoyo Osoegawa Anthropological study of families by NGS of full-length HLA genes to determine haplotype segregation in multiple populations. Samples from family quartets consisting of two parents and at least two non-HLA identical children or family trios consisting of one parent and at least two non-HLA…