Project name: HLA-associated type 1 diabetes in world populations Project leader(s): J. Noble Detailed project description: HLA association with type 1 diabetes has been studied by both individual groups and large consortia for more than 40 years, yet a dearth of information still exists in populations other than those of European descent. We have collected…
Genetic Diversity and Function of non-classical HLA genes and HLA Pseudogenes: Implications in Transplantation and MHC disease Association Project leaders: David Sayer, Julie Di Cristofaro, Julien Paganini Detailed project description: The goal of this workshop component is to understand the genetic diversity, possible function, importance in transplantation, MHC disease association and MHC structure and evolution,…
HLA and Immunogenetics | COVID-19 Consortium Project leaders: Jill A. Hollenbach, Steven J. Mack, Martin Maiers Detailed project description: The Consortium is a community effort to create a persistent community resource providing centralized access to COVID-19-related HLA and immunogenetic data, literature, and data analysis tools. This project is not providing protocols for sample collection or…
Project name: COVID-HLA-GENOME Project leader: Seiamak Bahram Steering committee: Martin Maiers (NMDP, US), Marco Colonna (Wash. U., US), Luca Vago (EFI, EU), Hidetoshi Inoko (JSHI, Japan) and Eric Spierings (IHIWS, The Netherlands), Robert Zeiser (Freiburg, Germany), Raphael Carapito (Strasbourg, France) International Scientific Advisory Committee: Erin J. Adams, University of Chicago, IL, USA Pamela J. Bjorkman,…
Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0. Hurley CK, Kempenich J, Wadsworth K, Sauter J, Hofmann JA, Schefzyk D, Schmidt AH, Galarza P, Cardozo MBR, Dudkiewicz M, Houdova L, Jindra P, Sorensen BS, Jagannathan L, Mathur A, Linjama T, Torosian T, Freudenberger R, Manolis A, Mavrommatis J, Cereb N, Manor…
Project name: Creating Fully Representative MHC Reference Haplotypes Project leader(s): Paul Norman Detailed project description: The human genome reference is a valuable resource for multiple branches of science, yet does not adequately represent human diversity, a shortcoming that is especially evident in the highly polymorphic MHC region. A fundamental endeavour of the IHIW was assembling…
Project name: Common, Intermediate and Well-Documented Alleles 3.0 Project leader(s): Jason Dehn (National Marrow Donor Program, Minneapolis, MN USA), Carolyn Katovich Hurley (Georgetown University, Washington DC USA), Jane Kempenich (NMDP), Kim Wadsworth (NMDP) Download CIWD 3.0.0 data Participating registries: NMDP/Be The Match-US and Mexico DKMS (Germany, Polska, UK, India, Americas) Argentine HSC Donors…
MIC genes in health and disease Project leaders: Raphael Carapito, Perrine Spinnhirny and Seiamak Bahram Detailed project description: The MIC gene family encodes a distinct family of MHC class I genes at the centromeric extremity of the MHC class I region. The family is characterized by two genes, MICA and MICB that encode highly glycosylated…
NGS HLA genes typing of Reference Cell Lines and Quality Control Project leader: Gonzalo Montero-Martin and Kazutoyo Osoegawa Detailed project description: Cell lines (collected historically by the previous workshops) were sequenced by multiple laboratories to obtain a complete NGS of full-length HLA genes typing. The consensus NGS HLA typing of 406 cell lines, extensively tested…
Population genetics, anthropology and evolution (PGAE) Project leaders: Alicia Sanchez-Mazas and Natasja De Groot Detailed project description: The project aims at building an up-to-data mapping of the HLA molecular polymorphism in human populations and at developing a well-grounded methodological framework to analyse these data in an anthropological/evolutionary perspective. The component is both traditional and new:…
